PLATINUM
6 Month Supply
Regular Price: $419.70
$29
.95
EACH
TOTAL: $179.70
YOU SAVE: $279
+ FREE SHIPPING IN US
Hi there, I’m Dr. Blake Myers, joint-health expert with over 10 years experience.
And today, I'm going to reveal a shockingly effective Joint Guardian Technique...
Plus a twist you won't see coming… Disclosing the REAL culprit behind relentless joint agony.
One single, out-of-control protein.
This seemingly innocent protein, designed to renew our tissues, is in reality a wolf in sheep's clothing!
As we age it morphs into an invisible, relentless pac-man, eating away at your cartilage.
Scholars worldwide are flabbergasted.
But a groundbreaking discovery backed by top scientific research from organizations like the National Institute of Health…
Effortlessly restores your mobility with smooth, comfortable movements...
And repairs damaged cartilage, stimulating its growth and keeping your bones healthy...
All so you can regain your independence and perform daily activities without pain or worry…
Just imagine being able to get up from your favorite chair without wincing in pain…
Or enjoying a leisurely walk holding hands with your spouse…
And reclaiming your favorite hobbies and activities, like pickleball, gardening, golf, or playing with your grandkids…
Activities you never thought you’d get back to…
Without feeling held back by your aching joints.
Now, I know these may sound like bold promises...
But I'm 100% confident standing behind these promises …
Because I’ve seen firsthand how blocking this single protein transforms lives…
It worked wonders for my own father...
And has transformed the lives of over 32,000 men and women aged 50 and above...
Former prisoners of their own bodies now living vibrant, active lives on their terms, joint pain a distant memory...
About Dr. Blake:
I’m a licensed naturopathic doctor, graduate of Bastyr University, and author of “The Natural Apothecary,”
I have over a decade of experience integrating natural medicine to help patients renew health.
Seeing countless patients—including my own father—battle persistent joint discomfort signaled better solutions were needed.
This drove me to combine science identifying root causes of pain with targeted nutrition to support the body’s incredible capacity to heal when properly aided.
As founder and teacher at Chiron Healing Arts, I’ve helped thousands find lasting relief. I’m thrilled to now share this breakthrough solution so you too can thrive freely again.
The Real Culprit Behind Achy Joints
Most joint-pain treatments, like over-the-counter pain relievers, injections and even prescription medications, never truly address the root cause of our aches and pains…
Because they only provide temporary relief and don't target the real culprit behind our joint discomfort…
And if you're wondering WHY our joints become so painful as we age…
The usual suspects like wear and tear and inflammation might play a small role…
But the REAL problem is something much more shocking…
Something nobody is talking about, even though it's right under our nose.
It’s called Matrix Metalloproteinase (MMP).
MMPs are a family of helper proteins that have an important job - they break down and reshape the matrix.
The matrix is all the stuff between our cells, kind of like the mortar between bricks. This includes proteins like collagen, enzymes, and other molecules.
The matrix gives our tissues form and structure.
There are actually many types of MMPs, each with slightly different jobs.
MMP-13 is one of them. MMP-13 is specialized to break down collagen, the main protein that makes up connective tissues like tendons, ligaments, and cartilage.
All MMPs start off folded up and inactive, like a closed pocket knife. This helps keep them under control.
When MMPs are needed, other proteins unfold and activate them, kind of like opening up the pocket knife to expose the blade.
Once activated, MMPs can start breaking down matrix proteins. They reshape the matrix a little at a time - cutting here, reforming there.
This recycling keeps our tissues healthy.
Unfolding the Shocking Truth;
Out-Of-Control Cartilage Breakdown
Problems happen if MMPs get overactivated. It's like an open pocket knife flailing around!
This can lead to too much of the matrix proteins getting cut.
For MMP-13, too much collagen breakdown damages cartilage and leads to joint stiffness and pain.
MMP-13 is the specific protein that predominates in our articular cartilage…
Articular cartilage is a smooth, white tissue that lines the ends of bones where they form joints.
It's a living tissue that helps bones glide smoothly over each other with minimal friction.
Articular cartilage's main functions include:
Cushioning
Lubricating
Shock Absorption
Studies have shown that MMP-13 levels start to rise in joint cartilage as we reach our 40s and 50s.
At the same time, our bodies start making less of the natural inhibitors that normally shut off MMP-13 activity.
This imbalance leads to innocent protein going rogue...
It becomes a relentless, cartilage-gobbling monster…
Turning our once-strong, flexible joints into achy, painful shadows of their former selves.
So it’s no wonder traditional methods for dealing with joint pain don't offer more than temporary relief.
And without that cushion, our bones start to rub against each other...
Causing the searing pain we experience each day.
Isn't that mind-blowing?
But don't lose hope just yet…
There is a breakthrough so significant that leading scientific journals can't stop raving about it.
Studies from institutions like PubMed, Wiley Online Library, and ScienceDirect all concur…
That it’s a way to regain control of our lives and finally put an end to insufferable joint pain.
Fighting Back Naturally
And relieving joint pain and regaining mobility is much simpler than most people think...
In fact, it's entirely natural and doesn't cost a fortune.
And once we understand the real cause of joint pain (which is this MMP protein going haywire) we can actually tackle the problem at its root.
The key to getting rid of joint pain and ing our freedom and independence...
Is to simply block and inhibit out-of-control MMP protein.
And that’s the secret behind the incredible results of my father and my patients.
They not only experienced a significant reduction in joint pain, but also regained their mobility, energy, and zest for life.
And the best part?
The entire solution comes down to a combination of natural extracts and compounds...
Each of which has been proven in multiple scientific studies to effectively block and inhibit the MMP protein…
So you too can start experiencing the life-changing benefits for yourself as soon as possible.
Flavonoid Phenomenon
The first incredible compound is Quercetin...
This naturally-occurring flavonoid is found in many fruits and vegetables, like apples, onions, and berries...
And it's been known for its powerful anti-inflammatory and antioxidant properties.
But what really makes Quercetin stand out is its ability to
target that pesky protein Matrix Metalloproteinase (MMP)...
As you already know, MMP is responsible for breaking down our cartilage and causing joint pain...
But Quercetin can help regulate MMP activity, ensuring that it doesn't go into overdrive and cause more damage than necessary.
There is a ton of astonishing research to back up these claims...
One study published in the Journal of Cellular and Molecular Medicine showed that Quercetin could significantly reduce MMP production and activity in joint tissue...
This means that it can directly address the root cause of joint pain by preventing excessive cartilage breakdown.
Another study from the Journal of Free Radical Biology and Medicine...
Found that Quercetin could reduce inflammation and oxidative stress in joint tissue...
Both of which are major contributors to joint pain and arthritis.
And it doesn't stop there...
Yet another study, published in the journal Molecules...
Demonstrated that Quercetin could protect joint cartilage from degradation by inhibiting the production of inflammatory molecules...
Helping to maintain the integrity of our joints and keep them healthy.
It's truly remarkable! But this is just one amazing ingredient that can help with your joint pain...
Himalayan Gold for Cartilage
The next one is an incredible herb called Boswellia, which has been used for centuries in Ayurvedic medicine.
Boswellia is actually a type of tree resin that's native to the dry regions of India, Africa, and the Middle East.
What makes Boswellia so special is that it contains a unique compound called AKBA, which stands for Acetyl-11-keto-β-boswellic acid.
This powerful compound has been proven to directly target and inhibit the MMP protein that's responsible for breaking down too much cartilage in our joints as we age.
In one study published in the Journal of Inflammation Research, scientists took a group of participants suffering from joint pain and gave half of them a Boswellia extract containing a high concentration of AKBA, while the other half received a placebo.
The results were astonishing!
The group who took the Boswellia extract saw a significant reduction in their joint pain and inflammation, while the placebo group showed no improvements.
The researchers concluded that the AKBA in Boswellia was directly responsible for these amazing results, as it effectively inhibited the MMP protein and prevented further cartilage breakdown.
But that's not all...
In another study, from the Journal of Ethnopharmacology, scientists found that participants who took Boswellia extract experienced a 46% reduction in joint pain, as well as significant improvement in their overall joint function.
Can you imagine how life-changing this could be?
By taking Boswellia, which directly targets the MMP protein, we could finally regain our mobility, independence, and quality of life.
No more feeling like prisoners in our own bodies, and no more missing out on precious moments with our loved ones.
A Legendary Ancient Spice
The next ingredient is a powerful spice that has been used for centuries in traditional medicine for its potent anti-inflammatory properties…
And science reveals how this fiery orange spice can help reverse age-related cartilage breakdown.
It’s all thanks to a unique compound called curcumin, which is found inside turmeric…
Curcumin has been scientifically proven to:
Inhibit the overactive MMP protein...
Reduce inflammation in our joints...
And even help rebuild damaged cartilage!
In fact, one study from the National Library of Medicine, where adults with arthritis took a curcumin supplement regularly...
Saw their joint pain and swelling significantly decrease…
The study concluded that curcumin's effects were comparable to those of conventional anti-inflammatory drugs!
Another study published in the Journal of Clinical Immunology found that curcumin effectively reduced inflammation and pain in people with rheumatoid arthritis…
And it did so without any adverse side effects!
And a 2023 research article published in Frontiers in Immunology…
Discovered that curcumin not only reduced joint inflammation…
But it also helped prevent cartilage breakdown by regulating the MMP protein!
So, just imagine the powerful combination of Quercetin, Boswellia, and Turmeric…
All working together inside your body…
Targeting the root cause of your joint pain by addressing the overactive MMP protein…
Helping to rebuild damaged cartilage and reduce inflammation…
Allowing you to regain your mobility, independence, and quality of life…
How much would your life change if you could finally enjoy activities you once loved…
And keep up with your grandkids and family without any pain?
The possibilities are truly amazing…
But this unique blend also included:
The Tropical Enzyme Breakthrough
A powerful dose of Bromelain, extracted from the core of the pineapple...
Is truly remarkable because...
Research has shown that Bromelain has strong anti-inflammatory properties and can help reduce joint pain and swelling...
One study even found that Bromelain was as effective as the prescription drug diclofenac in reducing pain in patients with osteoarthritis...
And another study published in the Journal of Clinical Rheumatology showed that Bromelain can significantly improve joint pain and function...
It's amazing what nature can provide!
The Organic Joint Saver Your Joints are Starving For But Can't Produce On Their Own
And to really make the Joint Guardian complete Methylsulfonylmethane, or MSM for short, was also included.
You see, this organic sulfur compound is found in certain plants, and it's known for its ability to improve joint flexibility and reduce pain and inflammation...
A clinical trial published in the Journal of the International Society of Sports Nutrition even showed that MSM can help reduce muscle damage and joint pain after intense exercise...
And another study found that MSM can enhance the production of substances that protect your joints, like hyaluronic acid and type-II collagen...
Imagine being able to move freely, without pain, and enjoy your favorite activities again!
The Essential Amino Acid for Flexibility
Then there’s the incredible power of Methionine...
An essential amino acid that our body can't produce on its own...
It turns out that Methionine can help reduce inflammation and promote the growth of new, healthy cartilage in our joints...
A study published in the Journal of Anatomy found that Methionine can significantly improve cartilage health and function...
And another study showed that it can even help protect our
joints from the damaging effects of arthritis...
Imagine feeling strong and resilient, with joints that can withstand the test of time!
Cartilage-Protecting Compounds
And, finally, two natural compounds that are known for their ability to support cartilage health and reduce joint pain... Glucosamine and Chondroitin.
In fact, they are the building blocks of healthy cartilage.
This is what your body naturally uses to form the cushioning in your joints.
Research has shown that, when taken together, they can be even more effective at improving joint function and reducing pain than when taken separately...
A study published in the Journal of Orthopaedic Surgery and Research found that Glucosamine and Chondroitin can significantly improve pain and function in patients with knee osteoarthritis...
And the National Center for Complementary and Integrative Health even states that these two compounds can help slow the progression of joint damage in people with osteoarthritis...
So there you have it...
These amazing, natural ingredients can work together to help you regain control of your life, reduce joint pain, and improve your overall quality of life.
Reclaim Your Freedom
And Imagine Life's Simple Joys Restored
Just envision doing all the things you once loved and things you’ve always wanted to do …
Finally taking that trip to Italy
Learning a new dance
Getting back to gardening
Joining that pickleball league
Playing on the floor with your grandchild
Or maybe just the simple things in life that you once took for granted like getting in and out of a car with ease, shopping, climbing stairs, reaching and bending.
Live a life free from the prison with this Joint Guardian.
Rave Reviews
Skeptical? Don't just take my word - hear from others on their journeys from joint agony to freedom.
Like Susan, a 63-year-old grandmother from Phoenix:
"I felt trapped in my own body, unable to keep up with my grandkids or enjoy my favorite hobbies. But after using the Joint Guardian technique, I'm pain-free and back to living my life on my terms. I can play with my grandkids, go for walks, and even dance again!"
And Mark, a 56-year-old retired firefighter from Chicago:
"My joint pain made even the simplest tasks unbearable. I felt like a burden on my family and friends. But after trying the Joint Guardian technique, I can't believe the difference it's made! I'm back to doing the things I love, and I feel like a new man."
Introducing the Joint Guardian Technique…
Ultra Flex
This game-changing formula is meticulously designed to rapidly alleviate your joint pain and inflammation...
Simply take two easy-to-swallow capsules once a day, preferably with food...
And prepare to be astounded by the transformation:
Within just days, you'll experience noticeable relief from your joint pain and inflammation...
Your mobility will improve, allowing you to effortlessly perform daily tasks that once seemed daunting...
And you'll regain your independence and zest for life...
No longer feeling like a burden on your loved ones or missing out on cherished moments with your family and friends...
Lab-Tested Purity and Potency
Ultra Flex is crafted with only the finest, ethically-sourced natural ingredients, each purity-tested to ensure maximum potency...
Which guarantees Ultra Flex is free of any harsh chemicals that could do more harm than good.
And each bottle is made in an FDA-inspected U.S. facility we personally oversee to ensure the highest quality...
That's why it's no surprise that Ultra Flex has become a sensation among those suffering from joint pain.
In just the last 6 months alone, over 32,000 grateful customers have discovered the life-changing power of Ultra Flex.
Men and women, aged 50 to 102, are sharing their newfound freedom from joint pain with their friends and family...
Even people who haven't yet experienced severe joint pain are taking Ultra Flex daily to maintain their joint health...
So keeping Ultra Flex in stock has been a monumental task.
Limited Stock
That's why it's crucial you secure as much Ultra Flex as possible right now.
We don't want your incredible progress to be halted before you've fully reclaimed your life.
For the best and longest-lasting results, take Ultra Flex daily for at least 180 days.
This gives time for your joints to fully repair damaged cartilage, and stimulate healthy bone and cartilage growth...
And ensures that your joint pain and inflammation never return.
Now imagine... Walking, dancing, and playing with your grandkids without a single twinge of pain...
Feeling confident and empowered as you easily complete everyday tasks and enjoy your favorite hobbies...
New Joint Vitality
Your life, filled with energy, vitality, and the freedom to live it on your terms...
That's the gift Ultra Flex can give you – and it's time for you to seize it.
Just picture yourself waking up each morning, swinging your legs out of bed and feeling that newfound freedom of movement in your joints...
The amazed look on your loved ones' faces when they see you effortlessly carrying out daily tasks you once struggled with...
No more hiding your pain or making excuses to avoid activities you used to love...
And because the ingredients in Ultra Flex are completely natural yet incredibly powerful...
The transformation doesn't just stop at the surface level either...
Instead, as these healing nutrients get absorbed into your body and work their magic on the root cause of joint pain...
You'll be repairing damaged cartilage and stimulating healthy bone and cartilage growth...
Which means virtually every aspect of your mobility and independence will noticeably improve as a result.
By taking just two capsules of Ultra Flex once a day, preferably with food...
You'll save yourself the time, money, and hassle associated with doctor visits, expensive prescriptions, and failed remedies...
And unlike all the temporary fixes you've likely tried in the past...
Ultra Flex is the only real solution to defeat joint pain and inflammation.
Restore Your Body’s Natural Balance…
By targeting the overactive Matrix Metalloproteinase protein and restoring your body's natural balance...
Which is why I think you'd agree that, even if we were charging $129.95 per bottle of Ultra Flex, it would be a bargain.
I mean, $129.95 to eliminate joint pain and regain your mobility and independence forever?
That's a no-brainer...
But the great news is that you're not going to be asked to invest anything close to $129.95 for a single bottle of Ultra Flex today.
Instead, you'll be able to get your hands on this breakthrough for less than $1 per day.
That's right...
For the most-discounted package, which also happens to be the most popular option with folks by far...
You'll be able to reclaim your freedom from joint pain for less than the cost of a candy bar...
Because you can stock up on six bottles of Ultra Flex for just $29.95 per bottle, with free shipping in the US.
That's a full six months of healing and protection...
And that's the ideal length to ensure that not only do you repair damaged cartilage and stimulate healthy bone and cartilage growth...
But you also eliminate every single trace of joint pain and inflammation from your body for good...
So that you don't just look healthier and more confident...
You restore every aspect of your mobility and independence on a cellular level too.
Free Gifts - $39.90 Value
Plus, as a bonus, you'll also receive two amazing ebooks: "10 Anti-Aging Foods You Should Eat Every Day" and "Detox Your Life for Better Aging" absolutely free - $39.90 Value when you purchase the Platinum Package.
Bonus #1 - A $19.95 Value
Detox Your Life for Better Aging
Aging well is about more than just looking good— it's about feeling energized, mentally sharp, and emotionally balanced. But in today's toxic world, aging gracefully can seem impossible.
Between chronic stress, unhealthy diets, sedentary lifestyles, and polluted environments, our bodies are constantly fighting against external toxins that accelerate the aging process.
You'll learn how to:
Detox your diet through anti-inflammatory whole foods and strategic supplementation
Create a soothing, clutter-free home that promotes relaxation
Reduce stress through mindfulness, meditation, yoga, and more
Support your body's detox systems through sweat-inducing activities, massage, and daily movement
These simple lifestyle tweaks will help you look and feel your absolute best at every age! It's never too late to embrace better living through detox. Get your copy today and start aging backwards!
Bonus #2 - A $19.95 Value
10 Anti-Aging Foods You
Should Eat Every Day
Turn Back the Clock with the Anti-Aging Power of Food.
Advances in science confirm that diet and lifestyle have a profound influence on how well we age. This book harnesses that research to help you take control of your health, maximize your vitality, and resist the unwanted effects of biological aging.
Learn how to leverage superfoods like leafy greens, fatty fish, berries, avocados, nuts and green tea to activate your body's natural defenses against age-related decline. Discover their potent compounds, anti-aging mechanisms of action, and ways to easily incorporate more into your routine. Simple, delicious recipes and meal ideas make it easy to tap into their longevity benefits.
Beyond diet, evidence-based lifestyle tweaks enhance these dietary strategies - more exercise, stress management, restful sleep, cognitive stimulation and social connection. A positive, proactive mindset ties everything together.
It's never too late to start optimizing your diet and lifestyle for a long health span. With this highly actionable guide, take control of the aging process, enhance your health at the cellular level, and embrace your longevity journey with knowledge, confidence and joy!
Plus, you're fully protected by our 90-day, no-questions-asked,
money-back guarantee.
Which allows you to try Ultra Flex risk-free for three full months.
But if you're unsatisfied for any reason…
Just contact our friendly customer service team for a full refund on all bottles.
That's our ironclad promise to you.
We firmly believe every company should operate this way - either you love Ultra Flex, or your money back.
It doesn't get much simpler than that, does it?
Either this works, or you get a refund - no questions asked.
So go ahead and grab your supply of Ultra Flex right now while we still have bottles in stock.
What are you waiting for? Get the Platinum
Ultra Flex™ Package today and SAVE $279
You'll enjoy free shipping on the 6-month option, saving you even more money. Plus two bonus eBooks - a $39.90 Value
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New Lease on an Active Life
Right now, you stand at a critical crossroads in your life.
Continue down the path you're on, and you'll likely keep dealing with the unbearable joint pain and inflammation…
Struggling with the lack of mobility, independence, and quality of life…
Feeling like a prisoner in your own body, destined to suffer…
Unable to enjoy the activities you once loved or keep up with your grandkids and family.
That's an option you could choose, I guess…
But isn't living your life this way downright exhausting?
And that's why, right now, I want to urge you in the strongest possible terms to choose the second option that's in front of you…
The one where you take a chance, invest in yourself, and discover the immense possibility of a pain-free future.
This is the option where you finally experience rapid relief from joint pain and inflammation…
Where you regain effortless mobility with smooth, comfortable movements…
Where you repair damaged cartilage and stimulate healthy bone and cartilage growth…
Where you increase your independence to perform daily activities without pain or worry…
And where you reclaim your favorite hobbies and activities, enjoying time with your family again without feeling held back.
This is the one where you sleep better, you feel better, and you live better day after day…
And it's right within your reach…
But you're the only one who can make this decision.
So go ahead and select from one of the deeply-discounted packages you see below.
And secure your supply of Ultra Flex while there are still bottles in stock.
PLATINUM
6 Month Supply
Regular Price: $419.70
$29
.95
EACH
TOTAL: $179.70
YOU SAVE: $279
+ FREE SHIPPING IN US
90-DAY MONEY BACK GUARANTEE
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FREQUENTLY ASKED QUESTIONS
As I mentioned earlier, Ultra Flex contains powerful natural ingredients that target the root cause of joint pain, which is the overactive Matrix Metalloproteinase (MMP) protein. This protein breaks down too much tissue in our joints as we age, leading to pain and inflammation. Ultra Flex helps to balance the activity of MMP, allowing your body to repair damaged cartilage, stimulate healthy bone and cartilage growth, and ultimately reduce joint pain and inflammation.
If you're suffering from joint pain, stiffness, or inflammation, Ultra Flex is designed for you. Whether you're experiencing age-related joint issues, arthritis, or just general discomfort, Ultra Flex can help improve your mobility and quality of life. Even if you're just starting to notice joint discomfort or worry about future joint health, Ultra Flex can be a proactive step in maintaining healthy joints.
Once you choose your package below, you'll go to our 100% secure checkout page. Just enter your payment information and place your order. And don't worry, there's no automatic billing or anything like that. After that, you'll receive your order of Ultra Flex in the next five to seven business days in a discreet package, which means you're less than a week away from starting your journey to healthier, pain-free joints.
No worries at all. Remember, Ultra Flex comes with a 90-day, money-back guarantee. That means you can order Ultra Flex today, then have a full 90 days to decide if it's right for you. If you're not thrilled with the results, simply call or email our customer service team, and we'll refund your investment.
That's a tough one. The goal is to help as many people as possible regain control of their lives and enjoy pain-free joints. But due to the high demand for natural solutions like Ultra Flex, and the challenges our world is facing right now, I can't guarantee how long the supply will last. That's why it's important to get Ultra Flex today, especially since it comes with a 90-day 100% money-back guarantee, which means there's zero risk for you. It's also why you should consider stocking up.
That's the easy part. Just click one of the buttons below and choose your package. Remember, you can save big by choosing our most popular six-bottle package. Just fill out your details on the next page to complete your order, and Ultra Flex will be in your hands within the next five to seven business days. Plus, there's no risk because of my ironclad, 90-day guarantee.
What are you waiting for? Get the Platinum
Ultra Flex™ Package today and SAVE $279
You'll enjoy free shipping on the 6-month option, saving you even more money. Plus two bonus eBooks - a $39.90 Value
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References
Meszaros, Evan, and Charles J. Malemud. “Prospects for Treating Osteoarthritis: Enzyme–Protein Interactions Regulating Matrix Metalloproteinase Activity.” Therapeutic Advances in Chronic Disease, vol. 3, no. 5, 2012, pp. 219-229, doi:10.1177/2040622312454157.
Li, Zhao, et al. “Alterations in the Expression of Inflammation-Related Genes in Peripheral Blood Cells After APAP Overdose in Humans.” Journal of Cellular and Molecular Medicine, vol. 17, no. 12, 2013, pp. 1597–1613.
Xu, Lin, and Yefu Li. “A Molecular Cascade Underlying Articular Cartilage Degeneration.” Current Drug Targets, vol. 21, no. 9, 2020
De Moraes, Izadora Quintela Souza, et al. “Inhibition of Matrix Metalloproteinases: A Troubleshooting for Dentin Adhesion.” Restorative Dentistry & Endodontics, vol. 45, no. 3, 2020.
Roelofs, Anke J., and Cosimo De Bari. “Osteoarthritis Year in Review 2023: Biology.” Osteoarthritis and Cartilage, vol. 32, no. 2, Feb. 2024.
Haleagrahara, Nagaraja, et al. “Flavonoid Quercetin-Methotrexate Combination Inhibits Inflammatory Mediators and Matrix Metalloproteinase Expression, Providing Protection to Joints in Collagen-Induced Arthritis.” Inflammopharmacology, vol. 26, no. 5, 2018, pp. 1219–1232.
Wang, Haiyan, et al. “Quercetin Prevents Osteoarthritis Progression Possibly via Regulation of Local and Systemic Inflammatory Cascades.” Journal of Cellular and Molecular Medicine, vol. , no. , 2023.
Hu, Yue, et al. “Quercetin Alleviates Rat Osteoarthritis by Inhibiting Inflammation and Apoptosis of Chondrocytes, Modulating Synovial Macrophages Polarization to M2 Macrophages.” Free Radical Biology and Medicine, vol. 145, 2019, pp. 146–160.
Suzuki, Takuji, et al. “Anti-Inflammatory Effects of Dietary Polyphenols through Inhibitory Activity against Metalloproteinases.” Molecules, vol. 28, no. 14, 2023, p. 5426
Hu, Yue, et al. “Quercetin Alleviates Rat Osteoarthritis by Inhibiting Inflammation and Apoptosis of Chondrocytes, Modulating Synovial Macrophages Polarization to M2 Macrophages.” Free Radical Biology and Medicine, vol. 145, 2019, pp. 146–160.
Kim, Jinhak, et al. “Boswellia Serrata Extracts Ameliorates Symptom of Irregularities in Articular Cartilage through Inhibition of Matrix Metalloproteinases Activation and Apoptosis in Monosodium-Iodoacetate-Induced Osteoarthritic Rat Models.” Preventive Nutrition and Food Science, vol. 28, no. 3, 2023.
Rose, Brandon J., and David L. Kooyman. “A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage Biology.” Disease Markers, 2016.
Butawan, Matthew, et al. “Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement.” Nutrients, vol. 9, no. 3, 2017.
Pothacharoen, Peraphan, et al. “Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling.” Plants, vol. 10, no. 11, 2021.
Walker, A.F., et al. “Bromelain Reduces Mild Acute Knee Pain and Improves Well-Being in a Dose-Dependent Fashion in an Open Study of Otherwise Healthy Adults.” Phytomedicine, vol. 9, no. 8, 2002.
Brien, S., et al. “Bromelain as an Adjunctive Treatment for Moderate-to-Severe Osteoarthritis of the Knee: A Randomized Placebo-Controlled Pilot Study.” QJM: An International Journal of Medicine, vol. 99, no. 12, 2006.
"Bromelain." Mount Sinai Health Library, Mount Sinai Health System, www.mountsinai.org/health-library/supplement/bromelain.
Mogharrabi, Marzieh, et al. “The Effects of Nanomicelle of Curcumin on the Matrix Metalloproteinase (MMP-2, 9) Activity and Expression in Patients with Coronary Artery Disease (CAD): A Randomized Controlled Clinical Trial.” ARYA Atherosclerosis, vol. 16, no. 3, 2020.
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